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INTRODUCTION
OUTLINE
  • A01 Molecular Control
  • A02 Structure Construction
  • A03 Function Exploration
ORGANIZATION
  • A01 Molecular Control
  • A02 Structure Construction
  • A03 Function Exploration
MEETINGS
ACHIEVEMENTS
TOPICS
PUBLICATIONS
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Profile
Akira SHIGENAGA,
Assistant Professor
Institute of Health Biosciences and Graduate School of Pharmaceutical Sciences, The University of Tokushima
Contact Information
Address: Shomachi, Tokushima, 770-8505
E-mail: shigenaga.akira“at”tokushima-u.ac.jp (but replace "at" with "@")
Personal Homepage：http://www.tokushima-u.ac.jp/ph/faculty/labo/otaka/
Fields of Interest
Synthetic Organic Chemistry, Peptide Chemistry, Chemistry of Caged Compound
Professional Experience
1998-2004 Undergraduate & Graduate research, The University of Tokushima (M. Shibuya)
2004-2005 Research Associate, The Scripps Research Institute
2005-2007 Staff Scientist, The University of Tokushima
2007- present Assistant Professor, The University of Tokushima
Education
Ph. D., The University of Tokushima, 2004
Membership of Academic Societies
The Pharmaceutical Society of Japan, The Japanese Peptide Society, Japanese Society for Chemical Biology, The Society of Synthetic Organic Chemistry, Japan, American Chemical Society
Awards & Honors
  1. Koraku Award (1999)
  2. Ajinomoto Award in Synthetic Organic Chemistry, Japan (2006)
  3. Poster Award, The Second Annual Meeting of Japanese Society for Chemical Biology (2007)
  4. Young Investigator Award, The University of Tokushima (2010)
  5. Young Investigator Award, The Pharmaceutical Society of Japan, Chugoku-Shikoku Branch (2011)
  6. Young Investigator Award, The Japanese Peptide Society (2012)
  7. Takeda Pharmaceutical Company Award in Synthetic Organic Chemistry, Japan (2013)
Research Project
Design and Synthesis of Caged Protein for Spatiotemporal Control of Biomineralization
Selected Publications
  1. Shigenaga, A., Ogura, K., Hirakawa, H., Yamamoto, J., Ebisuno, K., Miyamoto, L., Ishizawa, K., Tsuchiya, K., Otaka, A.
    “Development of a Reduction-Responsive Amino Acid that Induces Peptide Bond Cleavage in Hypoxic Cells”,
    ChemBioChem, 13, 968-971 (2012).

  2. Shigenaga, A.
    “Development of Stimulus-Responsive Amino Acids and Their Application to Chemical Biology Use”,
    J. Pharm. Soc. Jpn., 132, 1075-1082 (2012).

  3. Shigenaga, A., Morishita, K., Yamaguchi, K., Ding, H., Ebisuno, K., Sato, K., Yamamoto, J., Akaji, K., Otaka, A.
    “Development of UV-Responsive Catch-and-Release System of a Cysteine Protease Model Peptide”,
    Tetrahedron, 67, 8879-8886 (2011).

  4. Shigenaga, A., Hirakawa, H., Yamamoto, J., Ogura, K., Denda, M., Yamaguchi, K., Tsuji, D., Itoh, K., Otaka, A.
    “Design and Synthesis of Caged Ceramide: UV-Responsive Ceramide Releasing System Based on UV-Induced Amide Bond Cleavage Followed by O-N Acyl Transfer”,
    Tetrahedron, 67, 3984-3990 (2011).

  5. Ding, H., Shigenaga, A., Sato, K., Morishita, K., Otaka, A.
    “Dual Kinetically-Controlled Native Chemical Ligation Using a Combination of Sulfanylproline and Sulfanylethylanilide Peptide” ,
    Org. Lett., 13, 5588-5591 (2011).

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